Metabolites Associated With the Risk of Incident Venous Thromboembolism: A Metabolomic Analysis

Background Venous thromboembolism ( VTE ) is a complex thrombotic disorder that constitutes a major source of mortality and morbidity. To improve understanding of the cause of VTE , we conducted a metabolomic analysis in a case-control study including 240 incident VTE cases and 6963 controls nested...

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Bibliographic Details
Published in:Journal of the American Heart Association 2018-11, Vol.7 (22), p.e010317
Main Authors: Jiang, Xia, Zeleznik, Oana A, Lindström, Sara, Lasky-Su, Jessica, Hagan, Kaitlin, Clish, Clary B, Eliassen, A Heather, Kraft, Peter, Kabrhel, Christopher
Format: Article
Language:English
Subjects:
Age Factors
Alcohol Drinking - adverse effects
Body Mass Index
carnitine
Carnitine - biosynthesis
Case-Control Studies
Diglycerides - blood
Female
Humans
incidence
lipids
Logistic Models
Male
Medicin och hälsovetenskap
metabolite
metabolome
Metabolomics
Middle Aged
Original Research
pulmonary embolism
Risk Factors
Sex Factors
Smoking - adverse effects
Venous Thromboembolism - blood
Venous Thromboembolism - etiology
Venous Thromboembolism - metabolism
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Summary:Background Venous thromboembolism ( VTE ) is a complex thrombotic disorder that constitutes a major source of mortality and morbidity. To improve understanding of the cause of VTE , we conducted a metabolomic analysis in a case-control study including 240 incident VTE cases and 6963 controls nested within 3 large prospective population-based cohorts, the Nurses' Health Study, the Nurses' Health Study II , and the Health Professionals Follow-Up Study. Methods and Results For each individual, we measured 211 metabolites and collected detailed information on lifestyle factors. We performed logistic regression and enrichment analysis to identify metabolites and biological categories associated with incident VTE risk, accounting for key confounders, such as age, sex, smoking, alcohol consumption, body mass index, and comorbid diseases (eg, cancers). We performed analyses of all VTEs and separate analyses of pulmonary embolism. Using the basic model controlling for age, sex, and primary disease, we identified 60 nominally significant VTE - or pulmonary embolism-associated metabolites ( P
ISSN:2047-9980
2047-9980
DOI:10.1161/JAHA.118.010317