Loading…

Invasion of the bucco-mandibular space by oral squamous cell carcinoma: histopathological analysis of invasion pattern

BackgroundThis study aimed to determine the patterns of invasion of oral squamous cell carcinoma (OSCC) into the bucco-mandibular space (BMS) using detailed histopathological analysis and to assess clinical outcomes.MethodsPatients with OSCC who underwent segmental mandibulectomy or hemi-mandibulect...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in oncology 2023-10, Vol.13, p.1168376-1168376
Main Authors: Kugimoto, Takuma, Nishii, Naoto, Oikawa, Yu, Kuroshima, Takeshi, Hirai, Hideaki, Tomioka, Hirofumi, Michi, Yasuyuki, Kayamori, Kou, Sakamoto, Junichiro, Iwanaga, Joe, Tubbs, R. Shane, Ikeda, Tohru, Miura, Masahiko, Harada, Hiroyuki
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:BackgroundThis study aimed to determine the patterns of invasion of oral squamous cell carcinoma (OSCC) into the bucco-mandibular space (BMS) using detailed histopathological analysis and to assess clinical outcomes.MethodsPatients with OSCC who underwent segmental mandibulectomy or hemi-mandibulectomy combined with resection of the BMS between 2012 and 2021 were included. The invasions of the BMS were classified into three patterns. Pattern A was defined as a horizontal invasion, Pattern B as a vertical invasion, and Pattern C as an expansive invasion.ResultsIn total, 109 patients were reviewed. Of these 109 patients, the primary tumor affected the lower gingiva in 78 patients, the buccal mucosa in 18 patients, and was a primary intraosseous carcinoma of the mandible in 13 patients. Invasion of the BMS was significantly associated with a higher pathological T stage, positive/close margins, and lower disease-free survival (DFS) rates. The DFS rates were 86.7% and 66.0% in the BMS non-invasion and invasion groups, respectively. The DFS rates for each type of invasion were 82.1% for Pattern A, 67.4% for Pattern B, and 48.0% for Pattern C (P=0.277).ConclusionPatients with BMS invasion have a poorer prognosis than those without invasion of the BMS. Therefore, adjuvant therapy is necessary, especially in Patterns B and C. Evaluation of preoperative BMS invasion patterns is important for predicting the prognosis of OSCC.
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2023.1168376