A microfluidic paper-based electrochemical biosensor array for multiplexed detection of metabolic biomarkers

Paper-based microfluidic devices have emerged as simple yet powerful platforms for performing low-cost analytical tests. This paper reports a microfluidic paper-based electrochemical biosensor array for multiplexed detection of physiologically relevant metabolic biomarkers. Different from existing p...

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Bibliographic Details
Published in:Science and technology of advanced materials 2013-10, Vol.14 (5), p.054402-7
Main Authors: Zhao, Chen, Thuo, Martin M, Liu, Xinyu
Format: Article
Language:English
Subjects:
Analytical chemistry
Arrays
Biomarkers
Biosensors
Chemical sensors
Cost analysis
Devices
Diagnostic systems
disease diagnostics
electrochemical detection
Focus on Nanomaterials and Nanofabrication for Biomedical Applications
Mathematical analysis
metabolic markers
Metabolism
Microfluidic devices
Microfluidics
Multiplexing
paper-based microfluidics
Platforms
Readers
Sensor arrays
Uric acid
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Summary:Paper-based microfluidic devices have emerged as simple yet powerful platforms for performing low-cost analytical tests. This paper reports a microfluidic paper-based electrochemical biosensor array for multiplexed detection of physiologically relevant metabolic biomarkers. Different from existing paper-based electrochemical devices, our device includes an array of eight electrochemical sensors and utilizes a handheld custom-made electrochemical reader (potentiostat) for signal readout. The biosensor array can detect several analytes in a sample solution and produce multiple measurements for each analyte from a single run. Using the device, we demonstrate simultaneous detection of glucose, lactate and uric acid in urine, with analytical performance comparable to that of the existing commercial and paper-based platforms. The paper-based biosensor array and its electrochemical reader will enable the acquisition of high-density, statistically meaningful diagnostic information at the point of care in a rapid and cost-efficient way.
ISSN:1468-6996
1878-5514
DOI:10.1088/1468-6996/14/5/054402