Evaluation of the efficacy of transcatheter arterial embolization combined with apatinib on rabbit VX2 liver tumors by intravoxel incoherent motion diffusion-weighted MR imaging

Background and purposeIt is crucial to evaluate the efficacy, recurrence, and metastasis of liver tumors after clinical treatment. This study aimed to investigate the value of Introvoxel Incoherent Motion (IVIM) imaging in the evaluation of rabbit VX2 liver tumors treated with Transcatheter Arterial...

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Bibliographic Details
Published in:Frontiers in oncology 2022-09, Vol.12, p.951587-951587
Main Authors: Chen, Can, Liu, Xiao, Deng, Lingling, Liao, Yunjie, Liu, Sheng, Hu, Pengzhi, Liang, Qi
Format: Article
Language:English
Subjects:
angiogenesis
apatinib
intravoxel incoherent motion
liver neoplasms
Oncology
transcatheter arterial embolization
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Summary:Background and purposeIt is crucial to evaluate the efficacy, recurrence, and metastasis of liver tumors after clinical treatment. This study aimed to investigate the value of Introvoxel Incoherent Motion (IVIM) imaging in the evaluation of rabbit VX2 liver tumors treated with Transcatheter Arterial Embolization (TAE) combined with apatinib. MethodsTwenty rabbit VX2 liver tumor models were established and randomly divided into either the experimental group (n=15) or the control group (n=5). The experimental group was treated with TAE combined with oral apatinib after successful tumor inoculation, while no treatment was administered following inoculation in the control group. IVIM sequence scan was performed in the experimental group before treatment, at 7 and 14 days after treatment. All rabbits were sacrificed after the last scan of the experimental group. Marginal tissues from the tumors of both groups were excised for immunohistochemical analysis to observe and compare the expression of microvessel density (MVD). The alterations of IVIM-related parameters of tumor tissues in the experimental group, including Apparent Diffusion Coefficient (ADC), True Diffusion Coefficient (D), Pseudodiffusion Coefficient (D*), and Perfusion Fraction (f) were compared at different periods, and the correlation between these parameters and MVD was analyzed. ResultsAfter treatment, ADC and D values significantly increased, whereas D* and f values both decreased, with statistically significant differences.(P
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2022.951587