Cutaneous mantle cell lymphoma: A rare case report

Cutaneous mantle cell lymphoma (MCL) is a very rare entity with very few cases reported till date. We report a case of 69-year-old man with generalized lymphadenopathy who was diagnosed with mitotically active B-cell lymphoma and a year later developed multiple large maculopapular skin rashes which...

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Bibliographic Details
Published in:Clinical dermatology review 2020-01, Vol.4 (1), p.61-63
Main Authors: Salwa Bano, Veena Ramaswamy, B N Tejaswini, Chaitra Chandrashekar
Format: Article
Language:English
Subjects:
cutaneous lymphoma
cyclin d1
mantle cell lymphoma
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Summary:Cutaneous mantle cell lymphoma (MCL) is a very rare entity with very few cases reported till date. We report a case of 69-year-old man with generalized lymphadenopathy who was diagnosed with mitotically active B-cell lymphoma and a year later developed multiple large maculopapular skin rashes which on biopsy showed infiltration of large atypical blast-like cells in the skin and on immunohistochemistry was in favor of MCL-blastoid variant. Skin involvement is rare in MCL, although in some cases, cutaneous manifestations are the first symptom. Skin involvement suggests a disseminated disease and is often associated with blastoid cytological features. Awareness of skin manifestations of MCL is crucial for dermatologists and hematologists for prompt diagnosis and timely treatment. Moreover, it has a dismal prognosis and shows a poor response to standard treatment.
ISSN:2542-551X
2542-5528
DOI:10.4103/CDR.CDR_58_18