Dietary and physical activity adaptations to alternate day modified fasting: implications for optimal weight loss

• Published in: Nutrition journal 2010-09, Vol.9 (1), p.35-35, Article 35
• Main Authors: Klempel, Monica C, Bhutani, Surabhi, Fitzgibbon, Marian, Freels, Sally, Varady, Krista A
• Format: Article
• Language: English
• Subjects: Adult; Aged; Body mass index; Calories; Care and treatment; Diet, Reducing - methods; Eating; Energy; Energy Intake; Energy Metabolism; Exercise; Fasting - physiology; Female; Food; Health aspects; Hormone replacement therapy; Humans; Hunger; Hyperphagia - physiopathology; Male; Meals; Metabolism; Middle Aged; Nutrition research; Obesity; Obesity - diet therapy; Patient Satisfaction; Physical fitness; Satiety Response - physiology; Weight control; Weight Loss
• ISSN: 1475-2891; 1475-2891
• DOI: 10.1186/1475-2891-9-35

Alternate day modified fasting (ADMF) is an effective strategy for weight loss in obese adults. The objective of this study was to examine the dietary and physical activity adaptations that occur during short-term ADMF, and to determine how these modulations affect rate of weight loss. Sixteen obese subjects (12 women/4 men) completed a 10-week trial consisting of 3 phases: 1) 2-week control phase, 2) 4-week ADMF controlled feeding phase, and 3) 4-week ADMF self-selected feeding phase. Body weight decreased (P < 0.001) by 5.6 ± 1.0 kg post-treatment. Energy intake on the fast day was 26 ± 3% of baseline needs (501 ± 28 kcal/d). No hyperphagic response occurred on the feed day (95 ± 6% of baseline needs consumed, 1801 ± 226 kcal/d). Daily energy restriction (37 ± 7%) was correlated to rate of weight loss (r = 0.42, P = 0.01). Dietary fat intake decreased (36% to 33% of kcal, P < 0.05) with dietary counseling, and was related to rate of weight loss (r = 0.38, P = 0.03). Hunger on the fast day decreased (P < 0.05) by week 2, and remained low. Habitual physical activity was maintained throughout the study (fast day: 6416 ± 851 steps/d; feed day: 6569 ± 910 steps/d). These findings indicate that obese subjects quickly adapt to ADMF, and that changes in energy/macronutrient intake, hunger, and maintenance of physical activity play a role in influencing rate of weight loss by ADMF.