Importance of Endogenous Fibrinolysis in Platelet Thrombus Formation

The processes of thrombosis and coagulation are finely regulated by endogenous fibrinolysis maintaining healthy equilibrium. When the balance is altered in favour of platelet activation and/or coagulation, or if endogenous fibrinolysis becomes less efficient, pathological thrombosis can occur. Arter...

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Bibliographic Details
Published in:International journal of molecular sciences 2017-08, Vol.18 (9), p.1850
Main Authors: Gue, Ying X, Gorog, Diana A
Format: Article
Language:English
Subjects:
Animals
Blood clots
Blood Coagulation
Blood Coagulation Tests
Blood Platelets - metabolism
cardiovascular
Cardiovascular diseases
Coagulation
endogenous
Fibrin
Fibrinolysis
Hemostasis
Humans
Measurement methods
Morbidity
platelets
Review
spontaneous
thrombolysis
Thrombosis
Thrombosis - blood
Thrombosis - diagnosis
Thrombosis - etiology
Thrombosis - metabolism
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Summary:The processes of thrombosis and coagulation are finely regulated by endogenous fibrinolysis maintaining healthy equilibrium. When the balance is altered in favour of platelet activation and/or coagulation, or if endogenous fibrinolysis becomes less efficient, pathological thrombosis can occur. Arterial thrombosis remains a major cause of morbidity and mortality in the world despite advances in medical therapies. The role endogenous fibrinolysis in the pathogenesis of arterial thrombosis has gained increasing attention in recent years as it presents novel ways to prevent and treat existing diseases. In this review article, we discuss the role of endogenous fibrinolysis in platelet thrombus formation, methods of measurement of fibrinolytic activity, its role in predicting cardiovascular diseases and clinical outcomes and future directions.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms18091850