CD4+FOXP3+ regulatory T cells are abundantly present in inflamed muscle of patients with juvenile dermatomyositis

Conclusion Treg in peripheral blood of JDM patients had a similar phenotype and frequency as peripheral blood Treg from age-matched controls. [...] Treg were present in inflamed muscle tissue, and could therefore be targets for specific treatment of disease.

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Bibliographic Details
Published in:Pediatric Rheumatology 2011-09, Vol.9 (S1), p.P63-P63, Article P63
Main Authors: Vercoulen, Yvonne, Elst, Elisabeth F, Meerding, Jenny, Plantinga, Maud, Varsani, Hemlata, van Schieveen, Christa, Bakker, Mette H, Klein, Mark, Spliet, Wim, de Weger, R, Wedderburn, Lucy, van Royen- Kerkhof, Annet, Prakken, Berent J
Format: Article
Language:English
Subjects:
Autoimmune diseases
Flow cytometry
Medical research
Pediatrics
Poster Presentation
Rheumatology
Online Access:Get full text
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Summary:Conclusion Treg in peripheral blood of JDM patients had a similar phenotype and frequency as peripheral blood Treg from age-matched controls. [...] Treg were present in inflamed muscle tissue, and could therefore be targets for specific treatment of disease.
ISSN:1546-0096
1546-0096
DOI:10.1186/1546-0096-9-S1-P63