Potential Therapeutic Effects of Gut Hormones, Ghrelin and Obestatin in Oral Mucositis

Chemotherapy and/or head and neck radiotherapy are frequently associated with oral mucositis. Oral pain, odynophagia and dysphagia, opioid use, weight loss, dehydration, systemic infection, hospitalization and introduction of a feeding tube should be mentioned as the main determinated effect of oral...

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Bibliographic Details
Published in:International journal of molecular sciences 2019-03, Vol.20 (7), p.1534
Main Authors: Stempniewicz, Agnieszka, Ceranowicz, Piotr, Warzecha, Zygmunt
Format: Article
Language:English
Subjects:
cancer
chemotheraphy
Endocrinology
ghrelin
gut hormone
Inflammatory bowel disease
Ischemia
obestatin
oral mucositis
Pancreatitis
Peptides
radiotherapy
Review
Rodents
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Summary:Chemotherapy and/or head and neck radiotherapy are frequently associated with oral mucositis. Oral pain, odynophagia and dysphagia, opioid use, weight loss, dehydration, systemic infection, hospitalization and introduction of a feeding tube should be mentioned as the main determinated effect of oral mucositis. Oral mucositis leads to a decreased quality of life and an increase in treatment costs. Moreover, oral mucositis is a life-threatening disease. In addition to its own direct life-threatening consequences, it can also lead to a reduced survival due to the discontinuation or dose reduction of anti-neoplasm therapy. There are numerous strategies for the prevention or treatment of oral mucositis; however, their effectiveness is limited and does not correspond to expectations. This review is focused on the ghrelin and obestatin as potentially useful candidates for the prevention and treatment of chemo- or/and radiotherapy-induced oral mucositis.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms20071534