Amelioration of Hepatotoxic and Neurotoxic Effect of Cartap by Aloe vera in Wistar Rats

Pesticide exposure can pose a serious risk to nontarget animals. Cartap is being broadly used in agricultural fields. The toxic effects of cartap on the levels of hepatotoxicity and neurotoxicity have not been properly studied in mammalian systems. Therefore, the present work focused on the effect o...

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Published in:Toxics (Basel) 2023-05, Vol.11 (5), p.472
Main Authors: Gupta, Vivek Kumar, Park, Uichang, Siddiqi, Nikhat J, Huh, Yun Suk, Sharma, Bechan
Format: Article
Language:English
Subjects:
Acetylcholinesterase
Agricultural land
Aloe vera
Animals
Antioxidants
Brain
Cartap
Enzymes
Hepatotoxicity
histopathology
Interleukin 6
Liver
Metabolites
Neurotoxicity
Nontarget organisms
Oxidation
Oxidative stress
Pesticides
Phosphatase
Phytochemicals
Proteins
Toxicity
Tumor necrosis factor-α
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Summary:Pesticide exposure can pose a serious risk to nontarget animals. Cartap is being broadly used in agricultural fields. The toxic effects of cartap on the levels of hepatotoxicity and neurotoxicity have not been properly studied in mammalian systems. Therefore, the present work focused on the effect of cartap on the liver and brain of Wistar rats and made an assessment of the ameliorating potential of . The experimental animals were divided into 4 groups, comprising six rats in each: Group 1-Control; Group 2- ; Group 3-Cartap; and Group 4- + Cartap. The animals orally given cartap and were sacrificed after 24 h of the final treatment and histological and biochemical investigations were conducted in liver and brain of Wistar rats. Cartap at sublethal concentrations caused substantial decreases in CAT, SOD, and GST levels in the experimental rats. The activity levels of transaminases and phosphatases in cartap group were also found to be substantially altered. The AChE activity was recorded as decreasing in RBC membrane and brain of the cartap-treated animals. The TNF-α and IL-6 level in serum were increased expressively in the cartap challenged groups. Histological investigation of liver showed disorganized hepatic cords and severely congested central veins due to cartap. However, the extract was observed to significantly protect against the effects of cartap toxicity. The protective impact of against cartap toxicity may be due to the existence of antioxidants in it. These findings suggest that may be developed as a potential supplement to the appropriate medication in the treatment of cartap toxicity.
ISSN:2305-6304
2305-6304
DOI:10.3390/toxics11050472