Assessment of Subclinical Renal Glomerular and Tubular Dysfunction in Children with Beta Thalassemia Major

A good survival rate among patients with beta thalassemia major (beta-TM) has led to the appearance of an unrecognized renal disease. Therefore, we aimed to assess the role of serum cystatin-C as a promising marker for the detection of renal glomerular dysfunction and N-acetyl beta-D-glucosaminidase...

Full description

Saved in:
Bibliographic Details
Published in:Children (Basel) 2021-02, Vol.8 (2), p.100
Main Authors: Mahmoud, Asmaa A, Elian, Doaa M, Abd El Hady, Nahla Ms, Abdallah, Heba M, Abdelsattar, Shimaa, Khalil, Fatma O, Abd El Naby, Sameh A
Format: Article
Language:English
Subjects:
Anemia
beta thalassemia major
Blood diseases
Blood tests
Blood transfusions
Chelation therapy
Creatinine
cystatin C
Electrolytes
Hematology
Hemoglobin
Hepatitis
Hypertension
Iron
iron overload
kidney injury molecule 1 (KIM-1)
Kidneys
N-acetyl beta-D-glucosaminidase (NAG)
Oxidative stress
Pediatrics
Potassium
Proteins
Regression analysis
Sample size
Sodium
Uric acid
Urine
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A good survival rate among patients with beta thalassemia major (beta-TM) has led to the appearance of an unrecognized renal disease. Therefore, we aimed to assess the role of serum cystatin-C as a promising marker for the detection of renal glomerular dysfunction and N-acetyl beta-D-glucosaminidase (NAG) and kidney injury molecule 1 (KIM-1) as potential markers for the detection of renal tubular injury in beta-TM children. This case-control study was implemented on 100 beta-TM children receiving regular blood transfusions and undergoing iron chelation therapy and 100 healthy children as a control group. Detailed histories of complete physical and clinical examinations were recorded. All subjected children underwent blood and urinary investigations. There was a significant increase in serum cystatin-C ( < 0.001) and a significant decrease in eGFR in patients with beta-TM compared with controls ( = 0.01). There was a significant increase in urinary NAG, KIM-1, UNAG/Cr, and UKIM-1/Cr ( < 0.001) among thalassemic children, with a significant positive correlation between serum cystatin-C, NAG and KIM-1 as regards serum ferritin, creatinine, and urea among thalassemic patients. A negative correlation between serum cystatin-C and urinary markers with eGFR was noted. Serum cystatin-C is a good marker for detection of glomerular dysfunction. NAG and KIM-1 may have a predictive role in the detection of kidney injury in beta-TM children.
ISSN:2227-9067
2227-9067
DOI:10.3390/children8020100