PEGylated Adenoviruses: From Mice to Monkeys

Covalent modification with polyethylene glycol (PEG), a non-toxic polymer used in food, cosmetic and pharmaceutical preparations for over 60 years, can profoundly influence the pharmacokinetic, pharmacologic and toxciologic profile of protein and peptide-based therapeutics. This review summarizes th...

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Bibliographic Details
Published in:Viruses 2010-02, Vol.2 (2), p.468-502
Main Authors: Wonganan, Piyanuch, Croyle, Maria A
Format: Article
Language:English
Subjects:
adenovirus
gene therapy
immune response
non-viral vectors
PEGylation
pharmacokinetics
Review
targeting
tolerance
toxicity
vaccine
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Summary:Covalent modification with polyethylene glycol (PEG), a non-toxic polymer used in food, cosmetic and pharmaceutical preparations for over 60 years, can profoundly influence the pharmacokinetic, pharmacologic and toxciologic profile of protein and peptide-based therapeutics. This review summarizes the history of PEGylation and PEG chemistry and highlights the value of this technology in the context of the design and development of recombinant viruses for gene transfer, vaccination and diagnostic purposes. Specific emphasis is placed on the application of this technology to the adenovirus, the most potent viral vector with the most highly characterized toxicity profile to date, in several animal models.
ISSN:1999-4915
1999-4915
DOI:10.3390/v2020468