Circulating Levels of Hydrogen Sulfide (H 2 S) in Patients with Age-Related Diseases: A Systematic Review and Meta-Analysis

Hydrogen sulfide (H S) is an endogenous gasotransmitter that promotes multiple biological effects in many organs and tissues. An imbalanced biosynthesis of H S has been observed in animal models of age-related pathological conditions. However, the results from human studies are inconsistent. We perf...

Full description

Saved in:
Bibliographic Details
Published in:Biomolecules (Basel, Switzerland) Switzerland), 2023-06, Vol.13 (7), p.1023
Main Authors: Piragine, Eugenia, Malanima, Marco Andrea, Lucenteforte, Ersilia, Martelli, Alma, Calderone, Vincenzo
Format: Article
Language:English
Subjects:
Age
age-related diseases
Aged
Aging
Animal models
Animals
Atherosclerosis
Bias
Biosynthesis
Chronic illnesses
Confounding (Statistics)
Content analysis
Cross-sectional studies
Diabetes
Disease
Enzymes
Gasotransmitters
Health aspects
Humans
Hydrogen Sulfide
Hypertension
kidney disease
Kidney Diseases
Localization
Meta-analysis
Oxidative stress
Physiology
Potassium
Software
Statistical analysis
Systematic Review
type 2 diabetes
Vascular diseases
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Hydrogen sulfide (H S) is an endogenous gasotransmitter that promotes multiple biological effects in many organs and tissues. An imbalanced biosynthesis of H S has been observed in animal models of age-related pathological conditions. However, the results from human studies are inconsistent. We performed a systematic review with meta-analysis of studies searched in Medline, Embase, Scopus, and CENTRAL databases. We included observational studies on patients with age-related diseases showing levels of H S in blood, plasma, or serum. All the analyses were carried out with R software. 31 studies were included in the systematic review and 21 in the meta-analysis. The circulating levels of H S were significantly reduced in patients with progressive, chronic, and degenerative diseases compared with healthy people (standardized mean difference, SMD: -1.25; 95% confidence interval, CI: -1.98; -0.52). When we stratified results by type of disorder, we observed a significant reduction in circulating levels of H S in patients with vascular disease (e.g., hypertension) (SMD: -1.32; 95% CI: -2.43; -0.22) or kidney disease (SMD: -2.24; 95% CI: -4.40; -0.08) compared with the control group. These results could support the potential use of compounds targeting the "H S system" to slow down the progression of many diseases in the elderly.
ISSN:2218-273X
2218-273X
DOI:10.3390/biom13071023