Progression in Vascular Cognitive Impairment: Pathogenesis, Neuroimaging Evaluation, and Treatment

Vascular cognitive impairment (VCI) defines an entire spectrum of neurologic disorders from mild cognitive impairment to dementia caused by cerebral vascular disease. The pathogenesis of VCI includes ischemic factors (e.g., large vessel occlusion and small vessel dysfunction); hemorrhagic factors (e...

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Bibliographic Details
Published in:Cell Transplantation 2019-01, Vol.28 (1), p.18-25
Main Authors: Zhang, Xin, Su, Jiabin, Gao, Chao, Ni, Wei, Gao, Xinjie, Li, Yuxin, Zhang, Jun, Lei, Yu, Gu, Yuxiang
Format: Article
Language:English
Subjects:
Blood flow
Cerebral blood flow
Cerebrovascular Disorders - diagnostic imaging
Cerebrovascular Disorders - drug therapy
Cerebrovascular Disorders - pathology
Cerebrovascular Disorders - therapy
Cognitive ability
Cognitive Dysfunction - diagnostic imaging
Cognitive Dysfunction - drug therapy
Cognitive Dysfunction - pathology
Cognitive Dysfunction - therapy
Dementia disorders
Dementia, Vascular - diagnostic imaging
Dementia, Vascular - drug therapy
Dementia, Vascular - pathology
Dementia, Vascular - therapy
Disease Progression
Drug therapy
Hemorrhage
Humans
Ischemia
Measuring techniques
Medical imaging
Neuroimaging
Neuroimaging - methods
Neuropsychological Tests
Pathogenesis
Psychology
Rehabilitation
Reviews
Structure-function relationships
Subarachnoid hemorrhage
Vascular dementia
Vascular diseases
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Summary:Vascular cognitive impairment (VCI) defines an entire spectrum of neurologic disorders from mild cognitive impairment to dementia caused by cerebral vascular disease. The pathogenesis of VCI includes ischemic factors (e.g., large vessel occlusion and small vessel dysfunction); hemorrhagic factors (e.g., intracerebral hemorrhage and subarachnoid hemorrhage); and other factors (combined with Alzheimer’s disease). Clinical evaluations of VCI mainly refer to neuropsychological testing and imaging assessments, including structural and functional neuroimaging, with different advantages. At present, the main treatment for VCI focuses on neurological protection, cerebral blood flow reconstruction, and neurological rehabilitation, such as pharmacological treatment, revascularization, and cognitive training. In this review, we discuss the pathogenesis, neuroimaging evaluation, and treatment of VCI.
ISSN:0963-6897
1555-3892
DOI:10.1177/0963689718815820