Epigenetic and microRNA regulation during osteoarthritis development [version 1; peer review: 3 approved]

Osteoarthritis (OA) is a common degenerative joint disease, the pathological mechanism of which is currently unknown. Genetic alteration is one of the key contributing factors for OA pathology. Recent evidence suggests that epigenetic and microRNA regulation of critical genes may contribute to OA de...

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Bibliographic Details
Published in:F1000 research 2015, Vol.4, p.1092
Main Authors: Chen, Di, Shen, Jie, Hui, Tianqian
Format: Article
Language:English
Subjects:
Cartilage Biology & Osteoarthritis
Cell Signaling
Control of Gene Expression
Dermatologic Pharmacology
Genomics
Musculoskeletal Pharmacology
Nuclear Structure & Function
Review
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Summary:Osteoarthritis (OA) is a common degenerative joint disease, the pathological mechanism of which is currently unknown. Genetic alteration is one of the key contributing factors for OA pathology. Recent evidence suggests that epigenetic and microRNA regulation of critical genes may contribute to OA development. In this article, we review the epigenetic and microRNA regulations of genes related to OA development. Potential therapeutic strategies may be developed on the basis of novel findings.
ISSN:2046-1402
2046-1402
DOI:10.12688/f1000research.6548.1