The comprehensive on-demand 3D bio-printing for composite reconstruction of mandibular defects

Background The mandible is a functional bio-organ that supports facial structures and helps mastication and speaking. Large mandible defects, generally greater than 6-cm segment loss, may require composite tissue reconstruction such as osteocutaneous-vascularized free flap which has a limitation of...

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Bibliographic Details
Published in:Maxillofacial plastic and reconstructive surgery 2022-10, Vol.44 (1), p.31-31, Article 31
Main Authors: Park, Han Ick, Lee, Jee-Ho, Lee, Sang Jin
Format: Article
Language:English
Subjects:
3D bio-printing technology
Biocompatibility
Bones
Defects
Dental implants
Dentistry
Integrated tissue
Mandibular defect
Medicine
Oral and Maxillofacial Surgery
Organ printing
Osteocutaneous-vascularized free flap
Plastic Surgery
Reconstruction of the mandible
Reconstructive surgery
Review
Skin
Teeth
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Summary:Background The mandible is a functional bio-organ that supports facial structures and helps mastication and speaking. Large mandible defects, generally greater than 6-cm segment loss, may require composite tissue reconstruction such as osteocutaneous-vascularized free flap which has a limitation of additional surgery and a functional morbidity at the donor site. A 3D bio-printing technology is recently developed to overcome the limitation in the composite reconstruction of the mandible using osteocutaneous-vascularized free flap. Review Scaffold, cells, and bioactive molecules are essential for a 3D bio-printing. For mandibular reconstruction, materials in a 3D bio-printing require mechanical strength, resilience, and biocompatibility. Recently, an integrated tissue and organ printing system with multiple cartridges are designed and it is capable of printing polymers to reinforce the printed structure, such as hydrogel. Conclusion For successful composite tissue reconstruction of the mandible, biologic considerations and components should be presented with a comprehensive on-demand online platform model of customized approaches.
ISSN:2288-8586
2288-8101
2288-8586
DOI:10.1186/s40902-022-00361-7