A Fisetin Delivery System for Neuroprotection: A Co-Amorphous Dispersion Prepared in Supercritical Carbon Dioxide

Fisetin (FIS), a senolytic flavonoid, mitigates age-related neuroprotective changes. An amorphous FIS dispersion with a co-carrier was prepared using supercritical fluid extraction with carbon dioxide (scCO ). Characterisation, including powder X-ray diffraction and Fourier-transform infrared spectr...

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Bibliographic Details
Published in:Antioxidants 2024-01, Vol.13 (1), p.24
Main Authors: Sip, Szymon, Rosiak, Natalia, Sip, Anna, Żarowski, Marcin, Hojan, Katarzyna, Cielecka-Piontek, Judyta
Format: Article
Language:English
Subjects:
Acetylcholinesterase
Age
Aging
amorphous
Antioxidants
Apoptosis
Bioavailability
Brain research
Carbon dioxide
Cell death
fisetin
Flavonoids
Gram-negative bacteria
Inflammation
Infrared spectroscopy
Instrument industry
Intestinal microflora
Ligands
microbiome
Microbiomes
Microbiota
Microbiota (Symbiotic organisms)
Nervous system
Neurodegeneration
Neuroprotection
Oxidative stress
Polyphenols
Probiotics
Senescence
Solubility
Stroke
supercritical CO2
X-ray diffraction
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Summary:Fisetin (FIS), a senolytic flavonoid, mitigates age-related neuroprotective changes. An amorphous FIS dispersion with a co-carrier was prepared using supercritical fluid extraction with carbon dioxide (scCO ). Characterisation, including powder X-ray diffraction and Fourier-transform infrared spectroscopy, confirmed amorphization and assessed intermolecular interactions. The amorphous FIS dispersion exhibited enhanced solubility, dissolution profiles, and bioavailability compared to the crystalline form. In vitro, the amorphous FIS dispersion demonstrated antioxidant activity (the ABTS, CUPRAC, DDPH, FRAP assays) and neuroprotective effects by inhibiting acetylcholinesterase and butyrylcholinesterase. FIS modulated gut microbiota, reducing potentially pathogenic gram-negative bacteria without affecting probiotic microflora. These improvements in solubility, antioxidant and neuroprotective activities, and gut microbiome modulation suggest the potential for optimising FIS delivery systems to leverage its health-promoting properties while addressing oral functionality limitations.
ISSN:2076-3921
2076-3921
DOI:10.3390/antiox13010024