Modulation of nuclear receptor dependent transcription

Nuclear receptors comprise a family of transcription factors that regulate gene expression in a ligand dependent manner. They can activate or repress target genes by binding directly to DNA response elements as homo- or hetero-dimers or by binding to other classes of DNA-bound transcription factors....

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Bibliographic Details
Published in:Biological research 2002, Vol.35 (2), p.295-303
Main Author: Hart, Stephen M
Format: Article
Language:English
Subjects:
BIOLOGY
Eukaryotic Cells - physiology
Gene Expression Regulation - physiology
Humans
Ligands
Receptors, Cytoplasmic and Nuclear - chemistry
Receptors, Cytoplasmic and Nuclear - physiology
Structure-Activity Relationship
Transcription Factors - physiology
Transcription, Genetic
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Summary:Nuclear receptors comprise a family of transcription factors that regulate gene expression in a ligand dependent manner. They can activate or repress target genes by binding directly to DNA response elements as homo- or hetero-dimers or by binding to other classes of DNA-bound transcription factors. These activities have been linked to the formation of complexes with molecules that appear to serve as coactivators or corepressors, causing local modification of chromatin structure in order to regulate expression of their target genes. Several members of nuclear receptor family are directly associated with human malignancies including breast cancer, prostate cancer and leukaemia. The pathogenesis of each of these diseases is underpinned by the activities of a member of the superfamily; estrogen receptor-alpha (ER alpha) in breast cancer, androgen receptor (AR) in prostate cancer, and retinoic acid receptor alpha (RAR alpha) in acute promyelocytic leukaemia.
ISSN:0716-9760
0716-9760
0717-6287
DOI:10.4067/S0716-97602002000200021