Transcriptome Analysis Identifies Novel Mechanisms Associated with the Antitumor Effect of Chitosan-Stabilized Selenium Nanoparticles

Selenium nanoparticles (SeNPs) have been receiving special attention in recent years due to their antioxidant capacity and antitumor properties. However, the mechanisms associated with these properties remain to be elucidated. For this reason, a global transcriptome analysis has been designed in thi...

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Bibliographic Details
Published in:Pharmaceutics 2021-03, Vol.13 (3), p.356
Main Authors: Estevez, Hector, Garcia-Calvo, Estefania, Rivera-Torres, Jose, Vallet-Regí, María, González, Blanca, Luque-Garcia, Jose L
Format: Article
Language:English
Subjects:
Acids
antioxidant capacity
antitumor agent
Apoptosis
Breast cancer
Cancer therapies
Cell culture
Cell cycle
Chemotherapy
Cytotoxicity
Gene expression
Liver cancer
Nanoparticles
Selenium
selenium nanoparticles
Senescence
transcriptome analysis
tumor suppressors
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Summary:Selenium nanoparticles (SeNPs) have been receiving special attention in recent years due to their antioxidant capacity and antitumor properties. However, the mechanisms associated with these properties remain to be elucidated. For this reason, a global transcriptome analysis has been designed in this work and it was carried out using human hepatocarcinoma cells and chitosan-stabilized SeNPs (Ch-SeNPs) to identify new targets and pathways related to the antitumor mechanisms associated with Ch-SeNPs. The results obtained confirm the alteration of the cell cycle and the effect of Ch-SeNPs on different tumor suppressors and other molecules involved in key mechanisms related to cancer progression. Furthermore, we demonstrated the antioxidant properties of these nanoparticles and their capacity to induce senescence, which was further confirmed through the measurement of β-galactosidase activity.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics13030356