Design, synthesis and biological evaluation of new substituted benzofuran-based derivatives via C−H bond activation

A series of biologically active disubstituted benzofuran derivatives (3a?d) have been designed and synthesized via C?H bond activation reaction. The chemical structures of all final compounds were confirmed by spectroscopic methods. In vitro anti acetylcholinesterase (AChE) activities of these novel...

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Bibliographic Details
Published in:Journal of the Serbian Chemical Society 2020, Vol.85 (11), p.1405-1415
Main Authors: Pouramiri, Behjat, Zahedifar, Mahboobeh, Ayati, Adileh, Pouramiri, Farah, Ahmadi, Mahdiyeh
Format: Article
Language:English
Subjects:
acetylcholinesterase
alzheimer’s disease
benzofuran
carbon-carbon coupling
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Summary:A series of biologically active disubstituted benzofuran derivatives (3a?d) have been designed and synthesized via C?H bond activation reaction. The chemical structures of all final compounds were confirmed by spectroscopic methods. In vitro anti acetylcholinesterase (AChE) activities of these novel compounds were evaluated and showed low to moderate results. Among them, compound 3d moderately inhibited AChE activities with 68.12 % value.
ISSN:0352-5139
1820-7421
DOI:10.2298/JSC191231039P