Identification and Antioxidant Activity of Flavonoids Extracted from Xinjiang Jujube ( Ziziphus jujube Mill .) Leaves with Ultra-High Pressure Extraction Technology

In this study, the ultra-high pressure extraction (UHPE) conditions for obtaining the maximum flavonoid yield from Xinjiang jujube ( .) leaves (XJL) were optimized by response surface methodology (RSM). Box⁻Behnken design (BBD) was applied to evaluate the effects of four variables (extraction temper...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2018-12, Vol.24 (1), p.122
Main Authors: Zhang, Li, Liu, Pengzhan, Li, Linlin, Huang, Ying, Pu, Yunfeng, Hou, Xujie, Song, Lijun
Format: Article
Language:English
Subjects:
Acids
antioxidant activity
Antioxidants
Chinese medicine
flavonoid
Flavonoids
Glycosides
High pressure
Investigations
Kaempferol
Kinases
Pressure
Quercetin
Response surface methodology
Scavenging
Solvents
ultra-high pressure extraction
Ultrasonic imaging
UPLC-ESI-MS
Xinjiang jujube leaf
Yield
Ziziphus jujuba
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Summary:In this study, the ultra-high pressure extraction (UHPE) conditions for obtaining the maximum flavonoid yield from Xinjiang jujube ( .) leaves (XJL) were optimized by response surface methodology (RSM). Box⁻Behnken design (BBD) was applied to evaluate the effects of four variables (extraction temperature, pressure, time and liquid-to-solid ratio) on flavonoid yield. The results showed that the optimal flavonoid yield (25.45 ± 0.21 mg/g) was derived at 50.0 °C, 342.39 MPa, 11.56 min, and a liquid-to-solid ratio of 43.95 mL/g. Eight compounds were tentatively identified and quantified as kaempferol and quercetin glycosides with UPLC-ESI-MS. Compared to ultrasound-assisted extraction (UAE), UHPE can obtain higher concentrations of total flavonoids and stronger DPPH and ABTS radical-scavenging activities in a much shorter time. Therefore, UHPE is an alternative to UAE for obtaining flavonoids from XJL, which may be an optional method for large-scale industrial flavonoid extraction from XJL.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules24010122