Effect of electromyostimulation on intramyocellular lipids of the vastus lateralis in older adults: a randomized controlled trial

Background Excessive intramyocellular lipid (IMCL) accumulation is a primary cause of skeletal muscle insulin resistance, especially in older adults, and interventions that reduce IMCL contents are important to improve insulin sensitivity. Electromyostimulation (EMS)-induced changes in IMCL content...

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Published in:BMC musculoskeletal disorders 2021-06, Vol.22 (1), p.1-569, Article 569
Main Authors: Hioki, Maya, Kanehira, Nana, Koike, Teruhiko, Saito, Akira, Takahashi, Hideyuki, Shimaoka, Kiyoshi, Sakakibara, Hisataka, Oshida, Yoshiharu, Akima, Hiroshi
Format: Article
Language:English
Subjects:
1H-magnetic resonance spectroscopy
Aged
Aging
Angina pectoris
Blood biochemistry
Care and treatment
Electric stimulation
Energy substrate metabolism
Exercise
Experiments
Glucose
Health aspects
Insulin
Insulin resistance
Kinases
Laboratories
Lipids
Magnetic resonance spectroscopy
Membrane lipids
Metabolism
Metabolites
Muscle contraction
Muscles
Musculoskeletal system
Older people
Pain
Physical fitness
Skeletal muscle
Spectrum analysis
Testing
Thigh
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Summary:Background Excessive intramyocellular lipid (IMCL) accumulation is a primary cause of skeletal muscle insulin resistance, especially in older adults, and interventions that reduce IMCL contents are important to improve insulin sensitivity. Electromyostimulation (EMS)-induced changes in IMCL content in older adults remain unknown. The purpose of this study was to clarify the effects of a single bout of EMS on the IMCL content of the vastus lateralis muscle in older adults. Methods Twenty-two physically active, non-obese older men and women were randomly assigned to an EMS intervention group (69.0 [+ or -] 5.2 years, n = 12) or a control group (68.4 [+ or -] 3.5 years, n = 10). EMS was applied to the vastus lateralis (7 s on and 7 s off) for 30 min; control participants sat quietly for 30 min. IMCL content within the vastus lateralis was quantified with .sup.1H-magnetic resonance spectroscopy (n = 7 per group). Fasting plasma glucose and insulin values were determined from blood samples collected before and after the EMS intervention. Results EMS induced a significant reduction in plasma glucose (93.1 [+ or -] 9.6 to 89.5 [+ or -] 9.1 mg/dL, p < 0.01), but not IMCL content (15.7 [+ or -] 15.7 to 15.8 [+ or -] 13.1 mmol/kg wet weight, p = 0.49) or insulin (5.4 [+ or -] 2.4 to 4.7 [+ or -] 2.7 [mu]IU/mL, p = 0.18). In the control group, no changes in IMCL content in the vastus lateralis was observed after prolonged quiet sitting. Conclusion EMS intervention for 30 min induces changes in plasma glucose, but no changes in IMCL content in older adults. Trial registration University hospital Medical Information Network (UMIN) Center ID: UMIN000020126. Retrospectively registered on December 222,015. Keywords: Energy substrate metabolism, .sup.1H-magnetic resonance spectroscopy, Skeletal muscle, Blood biochemistry, Aging
ISSN:1471-2474
1471-2474
DOI:10.1186/s12891-021-04456-6