The Potential Predictive Role of Tumour Necrosis Factor-α, Interleukin-1β, and Monocyte Chemoattractant Protein-1 for COVID-19 Patients Survival

• Published in: Infection and drug resistance 2022-01, Vol.15, p.821-829
• Main Authors: Kumboyono, Kumboyono, Chomsy, Indah Nur, Iskandar, Agustin, Aryati, Aryati, Parwati, Ida, Wihastuti, Titin Andri
• Format: Article
• Language: English
• Subjects: Coronaviruses; COVID-19; cytokine; Disseminated infection; Enzyme-linked immunosorbent assay; IL-1β; Inflammation; Monocyte chemoattractant protein; Monocyte chemoattractant protein 1; Monocytes; Mortality; Original Research; Patients; Polymerase chain reaction; sars cov-2; Severe acute respiratory syndrome; Survival; survival predictors; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Tumors
• ISSN: 1178-6973; 1178-6973
• DOI: 10.2147/IDR.S348392

Tumour necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and monocyte chemoattractant protein-1 (MCP-1) are early phase cytokines often encountered when the body is exposed to severe acute respiratory syndrome-associated-coronavirus-2. TNF-α, IL-1β, and MCP-1 are pro-inflammatory cytokines critical in the defence response against systemic infection and injury. Therefore, TNF-α, IL-1β, and MCP-1 are the most aggressive responses to viral infections in the acute phase, so they can be used to determine the survival of coronavirus disease 2019 (COVID-19) patients. The study aimed to determine the levels of TNF-α, IL-1β, and MCP-1 as predictors of survival for COVID-19 patients. A prospective cohort study was conducted on confirmed COVID-19 by a reverse-transcriptase-polymerase-chain-reaction (RT-PCR) in 84 adults admitted to the hospital in Indonesia. TNF-α, IL-1β, and MCP-1 level were measured from serum subjects using the enzyme-linked immunosorbent assay. The results from logistic regression modelling of the survival status of COVID-19 patients based on TNF-α, IL-1β, and MCP-1 levels were significant (p-value=0.024). The predictors of all cytokines had P Wald