Radiological Evaluation of the effects of varied doses of Celecoxib on fracture healing in dogs

To determine if Cyclooxygenase -2 (COX-2) functions in fracture healing, 10 dogs were treated with COX-2-selective nonsteroidal anti-inflammatory drugs (Celecoxib) to reduce and stop COX-2-dependent prostaglandin production. Radiographic testing evaluation determined that fracture healing was not af...

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Bibliographic Details
Published in:Veterinary World 2011-02, Vol.4 (2), p.75-76
Main Author: Kene, Edwin
Format: Article
Language:English
Subjects:
Analgesia
Celecoxib
Cyclooxygenase
dog
Fracture healing
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Summary:To determine if Cyclooxygenase -2 (COX-2) functions in fracture healing, 10 dogs were treated with COX-2-selective nonsteroidal anti-inflammatory drugs (Celecoxib) to reduce and stop COX-2-dependent prostaglandin production. Radiographic testing evaluation determined that fracture healing was not affected in dogs treated with a low dose of COX-2-selective NSAIDs (celecoxib) and delayed union was observed in dogs treated with a high dose of COX-2-selective NSAIDs (celecoxib). Celecoxib dose of 5 mg/kg/day did not affect fracture callus formed in the study group and did not cause a significant increase in the proportion of delayed unions, however, at a dose of 10 mg/kg/day it reduced the rate of fracture callus formation and significantly increased the proportion of delayed unions for dogs in the group.
ISSN:0972-8988
2231-0916
DOI:10.5455/vetworld.2011.75-76