Gold-Based Medicine: A Paradigm Shift in Anti-Cancer Therapy?

A new era of metal-based drugs started in the 1960s, heralded by the discovery of potent platinum-based complexes, commencing with cisplatin [(H₃N)₂PtCl₂], which are effective anti-cancer chemotherapeutic drugs. While clinical applications of gold-based drugs largely relate to the treatment of rheum...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2018-06, Vol.23 (6), p.1410
Main Authors: Yeo, Chien Ing, Ooi, Kah Kooi, Tiekink, Edward R T
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - chemistry
Antineoplastic Agents - therapeutic use
Arthritis
biological activities
Cancer
Cancer therapies
Cell Line, Tumor
Cisplatin
Drug metabolism
Drugs
Gold
Gold - chemistry
Gold compounds
Humans
Metabolism
Platinum
Review
Rheumatoid arthritis
Therapeutic applications
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Summary:A new era of metal-based drugs started in the 1960s, heralded by the discovery of potent platinum-based complexes, commencing with cisplatin [(H₃N)₂PtCl₂], which are effective anti-cancer chemotherapeutic drugs. While clinical applications of gold-based drugs largely relate to the treatment of rheumatoid arthritis, attention has turned to the investigation of the efficacy of gold(I) and gold(III) compounds for anti-cancer applications. This review article provides an account of the latest research conducted during the last decade or so on the development of gold compounds and their potential activities against several cancers as well as a summary of possible mechanisms of action/biological targets. The promising activities and increasing knowledge of gold-based drug metabolism ensures that continued efforts will be made to develop gold-based anti-cancer agents.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules23061410