Successful twin pregnancy in a patient with parkin-associated autosomal recessive juvenile parkinsonism

Pregnancy in patients with Parkinson disease is a rare occurrence. To the best of our knowledge, the effect of pregnancy as well as treatment in genetically confirmed autosomal recessive juvenile parkinsonism (ARJP) has never been reported. Here, we report the first case of pregnancy in a patient wi...

Full description

Saved in:
Bibliographic Details
Published in:BMC neurology 2011-06, Vol.11 (1), p.72-72, Article 72
Main Authors: Serikawa, Takehiro, Shimohata, Takayoshi, Akashi, Mami, Yokoseki, Akio, Tsuchiya, Miwa, Hasegawa, Arika, Haino, Kazufumi, Koike, Ryoko, Takakuwa, Koichi, Tanaka, Keiko, Tanaka, Kenichi, Nishizawa, Masatoyo
Format: Article
Language:English
Subjects:
Adult
Antiparkinsonian agents
Care and treatment
Case Report
Case studies
Diagnosis
Female
Health aspects
Humans
Male
Mutation
Parkinson's disease
Parkinsonian Disorders - genetics
Pregnancy
Pregnancy Complications - genetics
Pregnancy Outcome
Pregnant women
Risk factors
Twins
Ubiquitin-Protein Ligases - genetics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Pregnancy in patients with Parkinson disease is a rare occurrence. To the best of our knowledge, the effect of pregnancy as well as treatment in genetically confirmed autosomal recessive juvenile parkinsonism (ARJP) has never been reported. Here, we report the first case of pregnancy in a patient with ARJP associated with a parkin gene mutation, ARJP/PARK2. A 27-year-old woman with ARJP/PARK2 was diagnosed as having a spontaneous dichorionic/diamniotic twin pregnancy. Exacerbation of motor disability was noted between ovulation and menstruation before pregnancy as well as during late pregnancy, suggesting that her parkinsonism might have been influenced by fluctuations in the levels of endogenous sex hormones. During the organogenesis period, she was only treated with levodopa/carbidopa, although she continued to receive inpatient hospital care for assistance in the activities of daily living. After the organogenesis period, she was administered sufficient amounts of antiparkinsonian drugs. She delivered healthy male twins, and psychomotor development of both the babies was normal at the age of 2 years. Pregnancy may worsen the symptoms of ARJP/PARK2, although appropriate treatments with antiparkinsonian drugs and adequate assistance in the activities of daily living might enable successful pregnancy and birth of healthy children.
ISSN:1471-2377
1471-2377
DOI:10.1186/1471-2377-11-72