Association between the immune-inflammation indicators and osteoarthritis - NHANES 1999–2018

Investigate the link between systemic immune-inflammatory index (SII) and Systemic Immune Response Index (SIRI) with osteoarthritis (OA) using National Health and Nutrition Examination Survey (NHANES) data (1999–2018). Extracted NHANES data (1999–2018) and selected a study population based on demogr...

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Bibliographic Details
Published in:Osteoarthritis and cartilage open 2025-03, Vol.7 (1), p.100453, Article 100453
Main Authors: Xue, Yan, Chang, Cheng, Chen, Yajun, Jia, Lang, Wang, Han, Liu, Zaoyang, Xie, Jiang
Format: Article
Language:English
Subjects:
ln-SII
NHANES
Osteoarthritis
RCS
Systemic immune response index
Systemic immune-inflammation index
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Summary:Investigate the link between systemic immune-inflammatory index (SII) and Systemic Immune Response Index (SIRI) with osteoarthritis (OA) using National Health and Nutrition Examination Survey (NHANES) data (1999–2018). Extracted NHANES data (1999–2018) and selected a study population based on demographic, examination, and laboratory data. Calculated SII (platelet count ​× ​neutrophil count/lymphocyte count) and SIRI (neutrophil count ​× ​monocyte count/lymphocyte count). Employed multivariate logistic regression and restricted cubic spline (RCS) regression for Ln-SII, SIRI, and OA relationship investigation. Conducted subgroup analyses. Study involved 32,144 participants (16,515 males, 15,629 females), with 12.16% having OA. Positive correlation between highest SII quartile and OA in unadjusted and adjusted model 1 (Unadjusted Model, P ​
ISSN:2665-9131
2665-9131
DOI:10.1016/j.ocarto.2024.100453