In vitro and in vivo antimicrobial potential of lithium complex against multi-drug resistant Acinetobacter baumannii

Multi-drug resistance (MDR) by virtue of evolving resistance and virulence mechanisms among is a global concern which is responsible for lethal hospital-acquired infections. Therefore, it is crucial to develop new therapeutics against it. Metal complexes are compact structures with diverse mechanism...

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Published in:Microbiology spectrum 2023-12, Vol.11 (6), p.e0193023-e0193023
Main Authors: Zehra, Moatter, Usmani, Yamina, Shafiq, Jazib, Khan, Ajmal, Zafar, Muneeza, Raza Mirza, Munazza, Shah, Syed Raza, Al-Harrasi, Ahmed, Hasan, Syed Mehmood, Farooqui, Amber, Ahmed, Ayaz
Format: Article
Language:English
Subjects:
Acinetobacter baumannii
biofilm
lithium complex
metal complexes
Microbial Pathogenesis
multi drug resistant
nosocomial infections
Research Article
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Summary:Multi-drug resistance (MDR) by virtue of evolving resistance and virulence mechanisms among is a global concern which is responsible for lethal hospital-acquired infections. Therefore, it is crucial to develop new therapeutics against it. Metal complexes are compact structures with diverse mechanisms that the pathogens cannot evade easily which make them a strong drug candidate. In this study, we assessed the and efficacy of lithium complex {[Li(phen) sal]} against biofilm-forming MDR . The lithium complex displayed strong antimicrobial activity and reduced the pre-formed mature biofilm which is key barrier for antimicrobial action. Moreover, it employs oxidative stress as one of its mode of actions and causes cellular rupturing. Lithium complex was non-toxic and was significantly effective to overcome pneumonia in mice model. These results highlight the untapped potential of metal complexes that can be explored and utilized for combating notorious infections.
ISSN:2165-0497
2165-0497
DOI:10.1128/spectrum.01930-23