The Molecular Impacts of Retrotransposons in Development and Diseases

Retrotransposons are invasive genetic elements that constitute substantial portions of mammalian genomes. They have the potential to influence nearby gene expression through their cis-regulatory sequences, reverse transcription machinery, and the ability to mold higher-order chromatin structures. Du...

Full description

Saved in:
Bibliographic Details
Published in:International journal of molecular sciences 2023-11, Vol.24 (22), p.16418
Main Authors: Tam, Phoebe Lut Fei, Leung, Danny
Format: Article
Language:English
Subjects:
Chromatin
diseases
DNA methylation
Embryonic development
Embryos
Epigenetics
epigenomics
Genes
Genetic transcription
Genomes
Genomics
Insects
mammalian development
Proteins
retrotransposons
Stem cells
Transposons
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Retrotransposons are invasive genetic elements that constitute substantial portions of mammalian genomes. They have the potential to influence nearby gene expression through their cis-regulatory sequences, reverse transcription machinery, and the ability to mold higher-order chromatin structures. Due to their multifaceted functions, it is crucial for host fitness to maintain strict regulation of these parasitic sequences to ensure proper growth and development. This review explores how subsets of retrotransposons have undergone evolutionary exaptation to enhance the complexity of mammalian genomes. It also highlights the significance of regulating these elements, drawing on recent studies conducted in human and murine systems.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms242216418