Crosstalk between the Tumor Microenvironment and Immune System in Pancreatic Ductal Adenocarcinoma: Potential Targets for New Therapeutic Approaches

Pancreatic ductal adenocarcinoma is a lethal disease for which radical surgery and chemotherapy represent the only curative options for a small proportion of patients. Recently, FOLFIRINOX and nab-paclitaxel plus gemcitabine have improved the survival of metastatic patients but prognosis remains poo...

Full description

Saved in:
Bibliographic Details
Published in:Gastroenterology research and practice 2018-01, Vol.2018 (2018), p.1-15
Main Authors: Giordano, Guido, Maiello, Evaristo, Latiano, Tiziana Pia, Pancione, Massimo, Remo, Andrea, Olivieri, Nunzio, Covelli, Claudia, Parcesepe, Pietro, Parente, Paola, Graziano, Paolo
Format: Article
Language:English
Subjects:
Adenocarcinoma
B cells
Cancer
Cancer therapies
Chemotherapy
Cytokines
Development and progression
Extracellular matrix
Growth factors
Health aspects
Hypoxia
Immune system
Immunotherapy
Medical prognosis
Metabolism
Metastasis
Oncology
Pancreatic cancer
Prognosis
Review
Systematic review
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Pancreatic ductal adenocarcinoma is a lethal disease for which radical surgery and chemotherapy represent the only curative options for a small proportion of patients. Recently, FOLFIRINOX and nab-paclitaxel plus gemcitabine have improved the survival of metastatic patients but prognosis remains poor. A pancreatic tumor microenvironment is a dynamic milieu of cellular and acellular elements, and it represents one of the major limitations to chemotherapy efficacy. The continued crosstalk between cancer cells and the surrounding microenvironment causes immunosuppression within pancreatic immune infiltrate increasing tumor aggressiveness. Several potential targets have been identified among tumor microenvironment components, and different therapeutic approaches are under investigation. In this article, we provide a qualitative literature review about the crosstalk between the tumor microenvironment components and immune system in pancreatic cancer. Finally, we discuss potential therapeutic strategies targeting the tumor microenvironment and we show the ongoing trials.
ISSN:1687-6121
1687-630X
DOI:10.1155/2018/7530619