RNA interference in glial cells for nerve injury treatment

Drivers of RNA interference are potent for manipulating gene and protein levels, which enable the restoration of dysregulated mRNA expression that is commonly associated with injuries and diseases. This review summarizes the potential of targeting neuroglial cells, using RNA interference, to treat n...

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Bibliographic Details
Published in:Journal of Tissue Engineering 2020, Vol.11, p.2041731420939224-2041731420939224
Main Authors: Lin, Junquan, Jo, Seung Bin, Kim, Tae-Hyun, Kim, Hae-Won, Chew, Sing Yian
Format: Article
Language:English
Subjects:
Central nervous system
Gene expression
Glial cells
Injuries
Interference
Nano-Bio-Technologies for Neural Regeneration
Ribonucleic acid
RNA
RNA-mediated interference
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Summary:Drivers of RNA interference are potent for manipulating gene and protein levels, which enable the restoration of dysregulated mRNA expression that is commonly associated with injuries and diseases. This review summarizes the potential of targeting neuroglial cells, using RNA interference, to treat nerve injuries sustained in the central nervous system. In addition, the various methods of delivering these RNA interference effectors will be discussed.
ISSN:2041-7314
2041-7314
DOI:10.1177/2041731420939224