The metabolic effects of resumption of a high fat diet after weight loss are sex dependent in mice

Dietary restriction is a frequent strategy for weight loss, but adherence is difficult and returning to poor dietary habits can result in more weight gain than that previously lost. How weight loss due to unrestricted intake of a healthy diet affects the response to resumption of poor dietary habits...

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Bibliographic Details
Published in:Scientific reports 2023-08, Vol.13 (1), p.13227-13227, Article 13227
Main Authors: Guerra-Cantera, Santiago, Frago, Laura M., Jiménez-Hernaiz, María, Collado-Pérez, Roberto, Canelles, Sandra, Ros, Purificación, García-Piqueras, Jorge, Pérez-Nadador, Iris, Barrios, Vicente, Argente, Jesús, Chowen, Julie A.
Format: Article
Language:English
Subjects:
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692/163
Astrocytes
Diet
Dietary restrictions
Glucose metabolism
High fat diet
Humanities and Social Sciences
Hypothalamus
Insulin-like growth factor II
Insulin-like growth factor-binding protein 2
Insulin-like growth factors
Males
Metabolic response
Metabolism
mRNA
multidisciplinary
Science
Science (multidisciplinary)
Sex
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Summary:Dietary restriction is a frequent strategy for weight loss, but adherence is difficult and returning to poor dietary habits can result in more weight gain than that previously lost. How weight loss due to unrestricted intake of a healthy diet affects the response to resumption of poor dietary habits is less studied. Moreover, whether this response differs between the sexes and if the insulin-like growth factor (IGF) system, sex dependent and involved in metabolic control, participates is unknown. Mice received rodent chow (6% Kcal from fat) or a high-fat diet (HFD, 62% Kcal from fat) for 4 months, chow for 3 months plus 1 month of HFD, or HFD for 2 months, chow for 1 month then HFD for 1 month. Males and females gained weight on HFD and lost weight when returned to chow at different rates (p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-40514-w