Effects of preoperative irradiation using fractioned electron beam on the healing process of colocolonic anastomosis in rats undergoing early and late surgical intervention

PURPOSE: To investigate the effects of preoperative fractioned irradiation using an electron beam on the healing process of colocolonic anastomoses in rats that underwent early and late surgical intervention. METHODS: Thirty Wistar rats, distributed as follows: group A (surgery only), group B (fract...

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Bibliographic Details
Published in:Acta cirúrgica brasileira 2013-01, Vol.28 (1), p.72-77
Main Authors: Simões Neto, Joaquim, Reis Neto, José Alfredo dos, Matos, Delcio
Format: Article
Language:English
Subjects:
Anastomosis, Surgical
Colon
Dose Fractionation
Rats
Surgical Procedures, Operative
Wound Healing
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Summary:PURPOSE: To investigate the effects of preoperative fractioned irradiation using an electron beam on the healing process of colocolonic anastomoses in rats that underwent early and late surgical intervention. METHODS: Thirty Wistar rats, distributed as follows: group A (surgery only), group B (fractionated irradiation for 30 days (if), surgery seven days after the end of it), group C (if for 30 days, and surgery after 30 days of termination). On the seventh postoperative day the anastomotic segment analysis was taken, using tension tests, histology and collagen deposition evaluation by computerized analysis. RESULTS: Regarding the tension resistance of the anastomosis, there were no statistical differences (p=0.42). However, a significant increase in cells number in the inflammatory infiltrate in the group with a longer interval between surgery and pre op radiation (p
ISSN:0102-8650
0102-8650
DOI:10.1590/S0102-86502013000100012