Nanogel Containing Gamma-Oryzanol-Loaded Nanostructured Lipid Carriers and TiO2/MBBT: A Synergistic Nanotechnological Approach of Potent Natural Antioxidants and Nanosized UV Filters for Skin Protection

The human skin is a recurring target of external aggressions, such as UV radiation, leading to exacerbation of the aging process and the occurrence of skin diseases, such as cancer. Hence, preventive measures should be taken to protect it against these aggressions, consequently decreasing the chance...

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Published in:Pharmaceuticals (Basel, Switzerland) Switzerland), 2023-04, Vol.16 (5), p.670
Main Authors: Badalkhani, Omolbanin, Pires, Patrícia C., Mohammadi, Maryam, Babaie, Soraya, Paiva-Santos, Ana Cláudia, Hamishehkar, Hamed
Format: Article
Language:English
Subjects:
antioxidant
Antioxidants
cosmeceuticals
Lipids
nanogel
Nanoparticles
nanostructured lipid carriers
natural-based
Particle size
Permeability
Skin diseases
skin protection
Sunscreen
Ultraviolet radiation
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Summary:The human skin is a recurring target of external aggressions, such as UV radiation, leading to exacerbation of the aging process and the occurrence of skin diseases, such as cancer. Hence, preventive measures should be taken to protect it against these aggressions, consequently decreasing the chance of disease development. In the present study, a topical xanthan gum nanogel containing gamma-oryzanol-loaded nanostructured lipid carriers (NLCs) and nanosized UV filters TiO2 and methylene bis-benzotriazolyl tetramethylbutylphenol (MBBT) was developed to assess their synergistic potential in having multifunctional skin beneficial properties. The developed NLCs contained the natural-based solid lipids shea butter and beeswax, liquid lipid carrot seed oil, and the potent antioxidant gamma-oryzanol, with an optimum particle size for topical application (
ISSN:1424-8247
1424-8247
DOI:10.3390/ph16050670