Impact of perioperative decreased serum albumin level on anastomotic leakage in esophageal squamous cell carcinoma patients treated with neoadjuvant chemotherapy followed by minimally invasive esophagectomy

Anastomotic leakage (AL) is a severe complication following esophagectomy with high mortality. Perioperative decreased serum albumin level is considered a predictive of AL, however, its impact on AL incidence in patients treated with neoadjuvant chemotherapy (NCT) followed by minimally invasive esop...

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Bibliographic Details
Published in:BMC cancer 2023-12, Vol.23 (1), p.1212-1212, Article 1212
Main Authors: Wang, Ying-Jian, Xie, Xian-Feng, He, Yi-Qiu, Bao, Tao, He, Xian-Dong, Li, Kun-Kun, Guo, Wei
Format: Article
Language:English
Subjects:
Adjuvant treatment
Albumin
Analysis
Anastomosis
Anastomotic leak
Anastomotic leakage
Cancer
Cancer therapies
Care and treatment
Chemotherapy
Complications
Development and progression
Diagnosis
Esophageal cancer
Esophageal carcinoma
Esophagus
Health aspects
Invasiveness
Lymphatic system
Measurement
Minimally invasive esophagectomy
Mortality
Neoadjuvant chemotherapy
Patients
Postoperative
Prevention
Risk factors
Serum albumin
Software
Squamous cell carcinoma
Surgery
Surgical anastomosis
Tomography
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Summary:Anastomotic leakage (AL) is a severe complication following esophagectomy with high mortality. Perioperative decreased serum albumin level is considered a predictive of AL, however, its impact on AL incidence in patients treated with neoadjuvant chemotherapy (NCT) followed by minimally invasive esophagectomy (MIE) is not well defined. The data of 318 consecutive esophageal cancer patients who underwent MIE were collected retrospectively from January 2021 to December 2021. The perioperative level of albumin was detected and the baseline of altering levels for albumin was established. The incidence of postoperative complications and survival rate were analyzed between groups. After exclusion, 137 patients were enrolled and assigned to more decreased albumin (MA) and less decreased albumin (LA) groups. The levels of albumin descended significantly after MIE (p 
ISSN:1471-2407
1471-2407
DOI:10.1186/s12885-023-11713-5