Effect of anticoagulant/antiplatelet therapy on the development and progression of diabetic retinopathy

We investigated whether antiplatelet/anticoagulant (APAC) therapy can protect patients with type 2 diabetes mellitus (T2DM) from the development or progression of diabetic retinopathy (DR). This is a retrospective cohort study using Longitudinal Health Insurance Database in Taiwan. A total of 73,964...

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Bibliographic Details
Published in:BMC ophthalmology 2022-03, Vol.22 (1), p.127-127, Article 127
Main Authors: Jeng, Chi-Juei, Hsieh, Yi-Ting, Lin, Cheng-Li, Wang, I-Jong
Format: Article
Language:English
Subjects:
Adult
Aggregation
Analysis
Anticoagulant
Anticoagulants
Antiplatelet
Aspirin
Blood platelets
Care and treatment
Comorbidity
Development and progression
Diabetes
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - drug therapy
Diabetes therapy
Diabetic retinopathy
Diabetic Retinopathy - drug therapy
Diabetic Retinopathy - epidemiology
Diabetic Retinopathy - etiology
Diabetics
Heart diseases
Humans
Hypertension
Kidney diseases
Macular Edema - epidemiology
Platelet Aggregation Inhibitors - therapeutic use
Retrospective Studies
Risk factors
Statins
Warfarin
Young Adult
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Summary:We investigated whether antiplatelet/anticoagulant (APAC) therapy can protect patients with type 2 diabetes mellitus (T2DM) from the development or progression of diabetic retinopathy (DR). This is a retrospective cohort study using Longitudinal Health Insurance Database in Taiwan. A total of 73,964 type 2 diabetic patients older than 20 years old were included. Hazard ration (HR) of non-proliferative DR (NPDR), proliferative DR (PDR), and diabetic macular edema (DME) were analyzed with APAC usage as a time-dependent covariate. Age, sex, comorbidities, and medicines were further adjusted in a multi-variable model. Contributions of respective APAC was investigated with sensitivity analysis. Compared with nonusers, APAC users had a lower cumulative incidence of NPDR (P 
ISSN:1471-2415
1471-2415
DOI:10.1186/s12886-022-02323-z