Geranylated Coumarins From Thai Medicinal Plant Mammea siamensis With Testosterone 5α-Reductase Inhibitory Activity

Geranylated coumarin constituents, kayeassamin I ( ) and mammeasins E ( ) and F ( ) were newly isolated from the methanol extract of the flowers of (Calophyllaceae) originating in Thailand, along with five known isolates, such as mammea E/BC ( ), deacetylmammea E/AA cyclo D ( ), deacetylmammea E/BB...

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Bibliographic Details
Published in:Frontiers in chemistry 2020-03, Vol.8, p.199-199
Main Authors: Morikawa, Toshio, Luo, Fenglin, Manse, Yoshiaki, Sugita, Hidemi, Saeki, Shunsuke, Chaipech, Saowanee, Pongpiriyadacha, Yutana, Muraoka, Osamu, Ninomiya, Kiyofumi
Format: Article
Language:English
Subjects:
5α-reductase inhibitor
calophyllaceae
Chemistry
geranylated coumarin
Mammea siamensis
mammeasin
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Summary:Geranylated coumarin constituents, kayeassamin I ( ) and mammeasins E ( ) and F ( ) were newly isolated from the methanol extract of the flowers of (Calophyllaceae) originating in Thailand, along with five known isolates, such as mammea E/BC ( ), deacetylmammea E/AA cyclo D ( ), deacetylmammea E/BB cyclo D ( ), mammea A/AA cyclo F ( ), and mammea A/AC cyclo F ( ). These compounds ( - ) were obtained as an inseparable mixture ( . 1:1 ratio) of the 3″ and 3″ forms, respectively. Among the isolated coumarins from the extract, mammeasins E ( , 22.6 μM), A ( , 19.0 μM), and B ( , 24.0 μM), kayeassamins E ( , 33.8 μM), F ( , 15.9 μM), and G ( , 17.7 μM), surangin C ( , 5.9 μM), and mammeas A/AA ( , 19.5 μM), E/BB ( , 16.8 μM), and A/AA cyclo F ( , 23.6 μM), were found to inhibit testosterone 5α-reductase.
ISSN:2296-2646
2296-2646
DOI:10.3389/fchem.2020.00199