UV Radiation in DNA Damage and Repair Involving DNA-Photolyases and Cryptochromes

Prolonged exposure to ultraviolet radiation on human skin can lead to mutations in DNA, photoaging, suppression of the immune system, and other damage up to skin cancer (melanoma, basal cell, and squamous cell carcinoma). We reviewed the state of knowledge of the damaging action of UVB and UVA on DN...

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Published in:Biomedicines 2021-10, Vol.9 (11), p.1564
Main Authors: Vechtomova, Yuliya, Telegina, Taisiya, Buglak, Andrey, Kritsky, Mikhail
Format: Article
Language:English
Subjects:
cancer
Carcinogenesis
Circadian rhythm
cryptochrome
Cryptochromes
Deoxyribonucleic acid
DNA
DNA damage
DNA repair
DNA-photolyase
Immune system
Melanoma
Mutation
Nucleotide excision repair
Pathogenesis
Photolyase
Review
ROS
Skin cancer
Squamous cell carcinoma
Transcription
ultraviolet
Ultraviolet radiation
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container_issue 11
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creator Vechtomova, Yuliya
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description Prolonged exposure to ultraviolet radiation on human skin can lead to mutations in DNA, photoaging, suppression of the immune system, and other damage up to skin cancer (melanoma, basal cell, and squamous cell carcinoma). We reviewed the state of knowledge of the damaging action of UVB and UVA on DNA, and also the mechanisms of DNA repair with the participation of the DNA-photolyase enzyme or of the nucleotide excision repair (NER) system. In the course of evolution, most mammals lost the possibility of DNA photoreparation due to the disappearance of DNA photolyase genes, but they retained closely related cryptochromes that regulate the transcription of the NER system enzymes. We analyze the published relationships between DNA photolyases/cryptochromes and carcinogenesis, as well as their possible role in the prevention and treatment of diseases caused by UV radiation.
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subjects cancer
Carcinogenesis
Circadian rhythm
cryptochrome
Cryptochromes
Deoxyribonucleic acid
DNA
DNA damage
DNA repair
DNA-photolyase
Immune system
Melanoma
Mutation
Nucleotide excision repair
Pathogenesis
Photolyase
Review
ROS
Skin cancer
Squamous cell carcinoma
Transcription
ultraviolet
Ultraviolet radiation
title UV Radiation in DNA Damage and Repair Involving DNA-Photolyases and Cryptochromes
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