Cornus mas L. Increases Glucose Uptake and the Expression of PPARG in Insulin-Resistant Adipocytes

L., also known as cornelian cherry (CM), is a species that has long been cultivated in many different countries. In numerous scientific reports, cornelian cherry is used to treat numerous diseases and conditions. The presented study evaluated the effect of red and yellow L. extract on insulin sensit...

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Bibliographic Details
Published in:Nutrients 2022-05, Vol.14 (11), p.2307
Main Authors: Małodobra-Mazur, Małgorzata, Cierzniak, Aneta, Ryba, Martyna, Sozański, Tomasz, Piórecki, Narcyz, Kucharska, Alicja Z
Format: Article
Language:English
Subjects:
Acids
Adipocytes
Antibiotics
Cornus mas
Cornus mas L
Diabetes
Flavonoids
Fruits
Gene expression
Glucose
glucose utilization
Insulin
Insulin resistance
Metabolism
Palmitic acid
Pathogenesis
Peroxisome proliferator-activated receptors
Phytochemicals
PPARG
Solvents
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Summary:L., also known as cornelian cherry (CM), is a species that has long been cultivated in many different countries. In numerous scientific reports, cornelian cherry is used to treat numerous diseases and conditions. The presented study evaluated the effect of red and yellow L. extract on insulin sensitivity in adipocytes. 3T3-L1 fibroblasts as well as human SAT-derived and VAT-derived adipocytes were differentiated in vitro, and insulin resistance was induced using palmitic acid (16:0). The effect of CM fruit extract was analyzed in terms of glucose uptake and insulin signaling gene expression. In the glucose uptake test after insulin stimulation, a significant increase in glucose uptake was demonstrated in cells treated with CM fruit extracts. Furthermore, CM fruit extracts increased the expression of insulin signaling genes in adipocytes stimulated with insulin in control cells and adipocytes treated with CM extract. Additionally, a significant increase in peroxisome proliferator activated receptor gamma ( expression was observed in cells supplemented with CM extract. In conclusion, studies have shown that CM fruits can overcome insulin resistance and thus they have a positive effect on cell metabolism.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu14112307