Reduced antibody cross-reactivity following infection with B.1.1.7 than with parental SARS-CoV-2 strains

The degree of heterotypic immunity induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains is a major determinant of the spread of emerging variants and the success of vaccination campaigns, but remains incompletely understood. We examined the immunogenicity of SARS-CoV-2 var...

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Bibliographic Details
Published in:eLife 2021-07, Vol.10
Main Authors: Faulkner, Nikhil, Ng, Kevin W, Wu, Mary Y, Harvey, Ruth, Margaritis, Marios, Paraskevopoulou, Stavroula, Houlihan, Catherine, Hussain, Saira, Greco, Maria, Bolland, William, Warchal, Scott, Heaney, Judith, Rickman, Hannah, Spyer, Moria, Frampton, Daniel, Byott, Matthew, de Oliveira, Tulio, Sigal, Alex, Kjaer, Svend, Swanton, Charles, Gandhi, Sonia, Beale, Rupert, Gamblin, Steve J, McCauley, John W, Daniels, Rodney Stuart, Howell, Michael, Bauer, David, Nastouli, Eleni, Kassiotis, George
Format: Article
Language:English
Subjects:
Antibodies
Antigen-antibody reactions
Asymptomatic
Computer software industry
Coronaviruses
COVID-19
COVID-19 vaccines
Cross-reactivity
Epidemiology and Global Health
Glycoproteins
Immunogenicity
Infections
Microbiology and Infectious Disease
Mutation
Parenting
SARS-CoV-2
Scientific equipment and supplies industry
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
Spike glycoprotein
Strains (organisms)
Vaccination
Viral antibodies
viral variant
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Summary:The degree of heterotypic immunity induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains is a major determinant of the spread of emerging variants and the success of vaccination campaigns, but remains incompletely understood. We examined the immunogenicity of SARS-CoV-2 variant B.1.1.7 (Alpha) that arose in the United Kingdom and spread globally. We determined titres of spike glycoprotein-binding antibodies and authentic virus neutralising antibodies induced by B.1.1.7 infection to infer homotypic and heterotypic immunity. Antibodies elicited by B.1.1.7 infection exhibited significantly reduced recognition and neutralisation of parental strains or of the South Africa variant B.1.351 (Beta) than of the infecting variant. The drop in cross-reactivity was significantly more pronounced following B.1.1.7 than parental strain infection. The results indicate that heterotypic immunity induced by SARS-CoV-2 variants is asymmetric.
ISSN:2050-084X
2050-084X
DOI:10.7554/eLife.69317