pH-Activated Dissolvable Polymeric Coatings to Reduce Biofouling on Electrochemical Sensors

Implantable electrochemical sensors that enable the real-time detection of significant biomarkers offer huge potential for the enhancement and personalisation of therapies; however, biofouling is a key challenge encountered by any implantable system. This is particularly an issue immediately after i...

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Published in:Journal of functional biomaterials 2023-06, Vol.14 (6), p.329
Main Authors: Uçar, Ahmet, González-Fernández, Eva, Staderini, Matteo, Murray, Alan F, Mount, Andrew R, Bradley, Mark
Format: Article
Language:English
Subjects:
Adsorption
Biofouling
Biomarkers
Chemical sensors
Coatings
dissolvable packaging
Dopamine
electrochemical sensing
Electrochemistry
Electrodes
Gold
Homogeneity
Hydration
Hydrogen-ion concentration
implantable devices
Implants, Artificial
Medical equipment
Methylene blue
Optimization
pH-activation
Polyethylene glycol
Polymer coatings
Polymers
Potassium
Prosthesis
Proteins
Sensors
Voltammetry
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cited_by cdi_FETCH-LOGICAL-c510t-9b28393cec69f1ccfe03128aad84a09094322030a438f833d764d06842cc4bdf3
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container_issue 6
container_start_page 329
container_title Journal of functional biomaterials
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creator Uçar, Ahmet
González-Fernández, Eva
Staderini, Matteo
Murray, Alan F
Mount, Andrew R
Bradley, Mark
description Implantable electrochemical sensors that enable the real-time detection of significant biomarkers offer huge potential for the enhancement and personalisation of therapies; however, biofouling is a key challenge encountered by any implantable system. This is particularly an issue immediately after implantation, when the foreign body response and associated biofouling processes are at their most active in passivating a foreign object. Here, we present the development of a sensor protection and activation strategy against biofouling, based on coatings consisting of a pH-triggered, dissolvable polymer, that covered a functionalised electrode surface. We demonstrate that reproducible delayed sensor activation can be achieved, and that the length of this delay can be controlled by the optimisation of coating thickness, homogeneity and density through tuning of the coating method and temperature. Comparative evaluation of the polymer-coated and uncoated probe-modified electrodes in biological media revealed significant improvements in their anti-biofouling characteristics, demonstrating that this offers a promising approach to the design of enhanced sensing devices.
doi_str_mv 10.3390/jfb14060329
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subjects Adsorption
Biofouling
Biomarkers
Chemical sensors
Coatings
dissolvable packaging
Dopamine
electrochemical sensing
Electrochemistry
Electrodes
Gold
Homogeneity
Hydration
Hydrogen-ion concentration
implantable devices
Implants, Artificial
Medical equipment
Methylene blue
Optimization
pH-activation
Polyethylene glycol
Polymer coatings
Polymers
Potassium
Prosthesis
Proteins
Sensors
Voltammetry
title pH-Activated Dissolvable Polymeric Coatings to Reduce Biofouling on Electrochemical Sensors
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