Circulating miR-184 is a potential predictive biomarker of cardiac damage in Anderson–Fabry disease

Enzyme replacement therapy (ERT) is a mainstay of treatment for Anderson–Fabry disease (AFD), a pathology with negative effects on the heart and kidneys. However, no reliable biomarkers are available to monitor its efficacy. Therefore, we tested a panel of four microRNAs linked with cardiac and rena...

Full description

Saved in:
Bibliographic Details
Published in:Cell death & disease 2021-12, Vol.12 (12), p.1150-7, Article 1150
Main Authors: Salamon, Irene, Biagini, Elena, Kunderfranco, Paolo, Roncarati, Roberta, Ferracin, Manuela, Taglieri, Nevio, Nardi, Elena, Laprovitera, Noemi, Tomasi, Luciana, Santostefano, Marisa, Ditaranto, Raffaello, Vitale, Giovanni, Cavarretta, Elena, Pisani, Antonio, Riccio, Eleonora, Aiello, Valeria, Capelli, Irene, La Manna, Gaetano, Galiè, Nazzareno, Spinelli, Letizia, Condorelli, Gianluigi
Format: Article
Language:English
Subjects:
38/77
38/90
692/53/2422
692/699/75
Antibodies
Biochemistry
Biomarkers
Biomedical and Life Sciences
Cell Biology
Cell Culture
Circulating MicroRNA
Discrimination
Enzyme Replacement Therapy
Fabry Disease - complications
Fabry Disease - diagnosis
Fabry Disease - genetics
Fabry's disease
Heart
Heart diseases
Humans
Immunology
Life Sciences
MicroRNAs - genetics
MicroRNAs - therapeutic use
miRNA
Patients
Reclassification
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Enzyme replacement therapy (ERT) is a mainstay of treatment for Anderson–Fabry disease (AFD), a pathology with negative effects on the heart and kidneys. However, no reliable biomarkers are available to monitor its efficacy. Therefore, we tested a panel of four microRNAs linked with cardiac and renal damage in order to identify a novel biomarker associated with AFD and modulated by ERT. To this end, 60 patients with a definite diagnosis of AFD and on chronic ERT, and 29 age- and sex-matched healthy individuals, were enrolled by two Italian university hospitals. Only miR-184 met both conditions: its level discriminated untreated AFD patients from healthy individuals (c-statistic = 0.7522), and it was upregulated upon ERT ( P  
ISSN:2041-4889
2041-4889
DOI:10.1038/s41419-021-04438-5