Components of the ribosome biogenesis pathway underlie establishment of telomere length set point in Arabidopsis

Telomeres cap the physical ends of eukaryotic chromosomes to ensure complete DNA replication and genome stability. Heritable natural variation in telomere length exists in yeast, mice, plants and humans at birth; however, major effect loci underlying such polymorphism remain elusive. Here, we employ...

Full description

Saved in:
Bibliographic Details
Published in:Nature communications 2019-12, Vol.10 (1), p.5479-8, Article 5479
Main Authors: Abdulkina, Liliia R., Kobayashi, Callie, Lovell, John T., Chastukhina, Inna B., Aklilu, Behailu B., Agabekian, Inna A., Suescún, Ana V., Valeeva, Lia R., Nyamsuren, Chuluuntsetseg, Aglyamova, Galina V., Sharipova, Margarita R., Shippen, Dorothy E., Juenger, Thomas E., Shakirov, Eugene V.
Format: Article
Language:English
Subjects:
38/22
38/77
38/88
45/43
631/337/103/560
631/449/1870
Arabidopsis
Arabidopsis - genetics
Arabidopsis - metabolism
Arabidopsis Proteins - genetics
Arabidopsis Proteins - metabolism
Biosynthesis
Cell proliferation
Chromosome Mapping
Chromosomes
Deoxyribonucleic acid
DNA
DNA biosynthesis
Elongation
Gene mapping
Genes
Humanities and Social Sciences
Mapping
multidisciplinary
Mutants
Polymorphism
Polymorphism, Genetic
Quantitative Trait Loci
Ribosomes - genetics
Ribosomes - metabolism
Science
Science (multidisciplinary)
Telomere - genetics
Telomere - metabolism
Telomeres
Yeast
Yeasts
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Telomeres cap the physical ends of eukaryotic chromosomes to ensure complete DNA replication and genome stability. Heritable natural variation in telomere length exists in yeast, mice, plants and humans at birth; however, major effect loci underlying such polymorphism remain elusive. Here, we employ quantitative trait locus (QTL) mapping and transgenic manipulations to identify genes controlling telomere length set point in a multi-parent Arabidopsis thaliana mapping population. We detect several QTL explaining 63.7% of the total telomere length variation in the Arabidopsis MAGIC population. Loss-of-function mutants of the NOP2A candidate gene located inside the largest effect QTL and of two other ribosomal genes RPL5A and RPL5B establish a shorter telomere length set point than wild type. These findings indicate that evolutionarily conserved components of ribosome biogenesis and cell proliferation pathways promote telomere elongation. Major effect loci controlling natural, heritable variation in telomere length are not known. Here, the authors use QTL mapping and transgenic manipulations in Arabidopsis to implicate the rRNA-processing genes NOP2A and RPL5 in telomere length set point regulation in this model species.
ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-019-13448-z