Mobilized Peripheral Blood Cells Administered Intravenously Produce Functional Recovery in Stroke

Filgratism (granulocyte colony stimulating factor, G-CSF)-mobilized peripheral blood progenitor cells (PBPCs) have replaced bone marrow (BM) as a preferred source of autologous stem cells, in light of the faster hematologic recovery and lesser supportive care requirement exhibited by PBPC transplant...

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Bibliographic Details
Published in:Cell transplantation 2003-01, Vol.12 (4), p.449-454
Main Authors: Willing, Alison E., Vendrame, Martina, Mallery, Jennifer, Cassady, C. Jordan, Davis, Cyndy D., Sanchez-Ramos, Juan, Sanberg, Paul R.
Format: Article
Language:English
Subjects:
Animals
Disease Models, Animal
Granulocyte Colony-Stimulating Factor - pharmacology
Hematopoietic Cell Growth Factors - pharmacology
Hematopoietic Stem Cell Mobilization - methods
Hematopoietic Stem Cells - cytology
Hematopoietic Stem Cells - drug effects
Hematopoietic Stem Cells - physiology
Hyperkinesis - etiology
Hyperkinesis - therapy
Infarction, Middle Cerebral Artery - therapy
Injections, Intravenous
Movement Disorders - etiology
Movement Disorders - therapy
Peripheral Blood Stem Cell Transplantation - methods
Rats
Rats, Sprague-Dawley
Recovery of Function - drug effects
Recovery of Function - physiology
Stem Cells - cytology
Stem Cells - drug effects
Stem Cells - physiology
Stroke - therapy
Treatment Outcome
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Summary:Filgratism (granulocyte colony stimulating factor, G-CSF)-mobilized peripheral blood progenitor cells (PBPCs) have replaced bone marrow (BM) as a preferred source of autologous stem cells, in light of the faster hematologic recovery and lesser supportive care requirement exhibited by PBPC transplants. Other hematopoietic stem cells, like the human umbilical cord blood-derived stem cells (hUCBs), and nonhematopoietic stem cells have been shown to improve motor function in rodent models of injury and degenerative disease. In the present study we transplanted either G-CSF-mobilized PBPCs or hUCBs in rats 24 h after permanent middle cerebral artery occlusion (MCAO), and assessed their behavioral abnormalities in spontaneous activity and spontaneous motor asymmetry. In both transplanted groups of rats we observed a significant reduction of the stroke-induced hyperactivity compared with nontransplanted, stroked animals. In addition, transplantation of G-CSF PBPC and hUCB cells prevented the development of extensive motor asymmetry. Our findings raise the possibility that PBPCs could provide a novel transplantation therapy to treat stroke.
ISSN:0963-6897
1555-3892
DOI:10.3727/000000003108746885