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Assessing the causal associations of different types of statins use and knee/hip osteoarthritis: A Mendelian randomization study

This study comprehensively evaluated the causal relationship between different types of statins use and knee/hip osteoarthritis (OA) using a two-sample and multivariate Mendelian randomization (MR) method. MR analysis was conducted using publicly available summary statistics data from genome-wide as...

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Bibliographic Details
Published in:PloS one 2024-04, Vol.19 (4), p.e0297766-e0297766
Main Authors: Chen, Xin, Huang, Xin, Liu, Youqun, Zhang, Zhiwei, Chen, Jiliang
Format: Article
Language:English
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Summary:This study comprehensively evaluated the causal relationship between different types of statins use and knee/hip osteoarthritis (OA) using a two-sample and multivariate Mendelian randomization (MR) method. MR analysis was conducted using publicly available summary statistics data from genome-wide association studies (GWAS) to assess the causal associations between total statins use (including specific types) and knee/hip OA. The primary analysis utilized the inverse variance-weighted (IVW) method, with sensitivity analysis conducted to assess robustness. Multivariable MR (MVMR) analysis adjusted for low-density lipoprotein cholesterol (LDL-C), intermediate-density lipoprotein cholesterol (IDL-C), high-density lipoprotein cholesterol (HDL-C), and body mass index (BMI). The MR analysis revealed a significant inverse association between genetically predicted total statins use and the risk of knee OA (OR = 0.950, 95%CI: 0.920-0.982, p = 0.002) as well as hip OA (OR = 0.932, 95%CI: 0.899-0.966, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0297766