Psoriasis may increase the risk of idiopathic pulmonary fibrosis: a two-sample Mendelian randomization study

Although some studies have indicated that Psoriasis could contribute to the risk of idiopathic pulmonary fibrosis (IPF), no study has reported a clear causal association between them. Our aim was to explore the potential relationship between Psoriasis and IPF using Mendelian randomization (MR) desig...

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Bibliographic Details
Published in:Respiratory research 2024-02, Vol.25 (1), p.101-101, Article 101
Main Authors: Chen, Lingli, Wei, Yujie, Hu, Mengjin, Liu, Yile, Zheng, Xiangrong
Format: Article
Language:English
Subjects:
Analysis
Biobanks
Care and treatment
Complications and side effects
Confounding (Statistics)
Diagnosis
Epidemiology
Estimates
Fibrosis
Genome-wide association studies
Genome-Wide Association Study
Genomes
Health risk assessment
Humans
Idiopathic pulmonary fibrosis
Idiopathic Pulmonary Fibrosis - diagnosis
Idiopathic Pulmonary Fibrosis - epidemiology
Idiopathic Pulmonary Fibrosis - genetics
Lung diseases
Mendelian randomization
Mendelian Randomization Analysis
Nonoxynol
Observational studies
Pneumonia
Psoriasis
Psoriasis - diagnosis
Psoriasis - epidemiology
Psoriasis - genetics
Psoriatic arthritis
Pulmonary fibrosis
Randomization
Risk factors
Skin diseases
Statistics
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Summary:Although some studies have indicated that Psoriasis could contribute to the risk of idiopathic pulmonary fibrosis (IPF), no study has reported a clear causal association between them. Our aim was to explore the potential relationship between Psoriasis and IPF using Mendelian randomization (MR) design. To explore a causal association between Psoriasis and IPF, we used genetic instruments from the largest available genome-wide association study (GWAS) of European ancestry, including psoriasis (5314 cases, 457,619 controls) and IPF (1028 cases, 196,986 controls). Our main analyses were conducted by inverse-variance weighted (IVW) method with random-effects model, with the other complementary four analyses: weighted median method, weighted mode, multivariable MR and MR-Egger approach. The results of IVW methods demonstrated that genetically predicted psoriasis was significantly associated with higher odds of IPF, with an odds ratio (OR) of 1.09 (95%CI, 1.01-1.18; P = 0.02). Weighted median method, weighted mode and multivariable MR also demonstrated directionally similar results (P 
ISSN:1465-993X
1465-9921
1465-993X
1465-9921
DOI:10.1186/s12931-024-02721-5