Excited-state intramolecular proton transfer of 2-acetylindan-1,3-dione studied by ultrafast absorption and fluorescence spectroscopy

We employ transient absorption from the deep-UV to the visible region and fluorescence upconversion to investigate the photoinduced excited-state intramolecular proton-transfer dynamics in a biologically relevant drug molecule, 2-acetylindan-1,3-dione. The molecule is a ß-diketone which in the elect...

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Bibliographic Details
Published in:Structural dynamics (Melville, N.Y.) N.Y.), 2016-03, Vol.3 (2), p.023606-023606
Main Authors: Verma, Pramod Kumar, Steinbacher, Andreas, Schmiedel, Alexander, Nuernberger, Patrick, Brixner, Tobias
Format: Article
Language:English
Subjects:
Absorption
Diketones
Excitation
Fluorescence
Ground state
Protons
SPECIAL TOPIC: SELECTED PAPERS FROM THE 3RD INTERNATIONAL CONFERENCE ON ULTRAFAST STRUCTURAL DYNAMICS
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Summary:We employ transient absorption from the deep-UV to the visible region and fluorescence upconversion to investigate the photoinduced excited-state intramolecular proton-transfer dynamics in a biologically relevant drug molecule, 2-acetylindan-1,3-dione. The molecule is a ß-diketone which in the electronic ground state exists as exocyclic enol with an intramolecular H-bond. Upon electronic excitation at 300 nm, the first excited state of the exocyclic enol is initially populated, followed by ultrafast proton transfer (≈160 fs) to form the vibrationally hot endocyclic enol. Subsequently, solvent-induced vibrational relaxation takes place (≈10 ps) followed by decay (≈390 ps) to the corresponding ground state.
ISSN:2329-7778
2329-7778
DOI:10.1063/1.4937363