Revisiting regulatory T cells for stroke therapy

Stroke is a leading cause of death and long-term disability. T cells have been extensively studied for their dual role in regulating immunity and inflammation following stroke. In this issue of the JCI, Cai, Shi, et al. demonstrated that CD8+ regulatory-like T cells (CD8+ TRLs) are one of the earlie...

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Bibliographic Details
Published in:The Journal of clinical investigation 2022-08, Vol.132 (15), p.1-3
Main Authors: Lee, Juneyoung, McCullough, Louise D
Format: Article
Language:English
Subjects:
Animals
Biomedical research
Brain
Brain injury
Brain Ischemia
Brain research
Care and treatment
CD8 antigen
Growth factors
Health aspects
Immunoregulation
Immunotherapy
Inflammation
Ischemia
Lymphocytes
Lymphocytes T
Mice
Mice, Inbred C57BL
Microbiota
Neurological diseases
Neurological disorders
Neutrophils
Physiological aspects
Stroke
Stroke (Disease)
Stroke - therapy
T cells
T-Lymphocytes, Regulatory
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Summary:Stroke is a leading cause of death and long-term disability. T cells have been extensively studied for their dual role in regulating immunity and inflammation following stroke. In this issue of the JCI, Cai, Shi, et al. demonstrated that CD8+ regulatory-like T cells (CD8+ TRLs) are one of the earliest lymphocyte subtypes to enter the brain after experimental ischemic stroke. Using a mouse model of stroke and comprehensive experimental approaches, the authors found that CD8+ TRLs reduced both brain damage and functional deficits in both young and aged mice. These unique early responding regulatory T cells may also play a role in a wide array of other T cell-mediated neurological disorders.
ISSN:1558-8238
0021-9738
1558-8238
DOI:10.1172/JCI161703