Continuous glucose monitoring captures glycemic variability in obesity after sleeve gastrectomy: A prospective cohort study

Objective HbA1c is an insensitive marker for assessing real‐time dysglycemia in obesity. This study investigated whether 1‐h plasma glucose level (1‐h PG) ≥155 mg/dL (8.6 mmol/L) during an oral glucose tolerance test (OGTT) and continuous glucose monitoring (CGM) measurement of glucose variability (...

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Bibliographic Details
Published in:Obesity science & practice 2024-02, Vol.10 (1), p.e729-n/a
Main Authors: Dorcely, Brenda, DeBermont, Julie, Gujral, Akash, Reid, Migdalia, Vanegas, Sally M., Popp, Collin J., Verano, Michael, Jay, Melanie, Schmidt, Ann Marie, Bergman, Michael, Goldberg, Ira J., Alemán, José O.
Format: Article
Language:English
Subjects:
Antihypertensives
Beta cells
Body mass index
Body weight loss
Cohort analysis
continuous glucose monitoring
Diabetes
Diabetes mellitus (non-insulin dependent)
Gastrectomy
Gastrointestinal surgery
Glucose monitoring
Glucose tolerance
glycemic variability
Hemoglobin
High density lipoprotein
Insulin resistance
Metabolism
Mortality
Obesity
sleeve gastrectomy
Software
Surgery
Variables
Weight control
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Summary:Objective HbA1c is an insensitive marker for assessing real‐time dysglycemia in obesity. This study investigated whether 1‐h plasma glucose level (1‐h PG) ≥155 mg/dL (8.6 mmol/L) during an oral glucose tolerance test (OGTT) and continuous glucose monitoring (CGM) measurement of glucose variability (GV) better reflected dysglycemia than HbA1c after weight loss from metabolic and bariatric surgery. Methods This was a prospective cohort study of 10 participants with type 2 diabetes compared with 11 participants with non‐diabetes undergoing sleeve gastrectomy (SG). At each research visit; before SG, and 6 weeks and 6 months post‐SG, body weight, fasting lipid levels, and PG and insulin concentrations during an OGTT were analyzed. Mean amplitude of glycemic excursions (MAGE), a CGM‐derived GV index, was analyzed. Results The 1‐h PG correlated with insulin resistance markers, triglyceride/HDL ratio and triglyceride glucose index in both groups before surgery. At 6 months, SG caused 22% weight loss in both groups. Despite a reduction in HbA1c by 3.0 ± 1.3% in the diabetes group (p 
ISSN:2055-2238
2055-2238
DOI:10.1002/osp4.729