Potential of Steroidal Alkaloids in Cancer: Perspective Insight Into Structure-Activity Relationships

Steroidal alkaloids contain both steroidal and alkaloid properties in terms of chemical properties and pharmacological activities. Due to outstanding biological activities such as alkaloids and similar pharmacological effects to other steroids, steroidal alkaloids have received special attention in...

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Bibliographic Details
Published in:Frontiers in oncology 2021-09, Vol.11, p.733369-733369
Main Authors: Huang, Ying, Li, Gen, Hong, Chong, Zheng, Xia, Yu, Haiyang, Zhang, Yan
Format: Article
Language:English
Subjects:
anticancer
drug design
medicinal potential
Oncology
steroidal alkaloids
structure–activity relationships
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Summary:Steroidal alkaloids contain both steroidal and alkaloid properties in terms of chemical properties and pharmacological activities. Due to outstanding biological activities such as alkaloids and similar pharmacological effects to other steroids, steroidal alkaloids have received special attention in anticancer activity recently. Substituted groups in chemical structure play markedly important roles in biological activities. Therefore, the effective way to obtain lead compounds quickly is structural modification, which is guided by structure-activity relationships (SARs). This review presents the SAR of steroidal alkaloids and anticancer, including pregnane alkaloids, cyclopregnane alkaloids, cholestane alkaloids, C-nor-D-homosteroidal alkaloids, and bis-steroidal pyrazine. A summary of SAR can powerfully help to design and synthesize more lead compounds.
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2021.733369